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M2 Courses:

 

Muddy Waters

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Week 1

Tuesday, August 4 - Location: 101 White Hall (WH)
 
Time
Lecturer
Lecture Title
Files
Media
  8:00 am–
8:20 am		 Raslich
I.1
Introduction 1
Reviewing Course Organization
PPT | HTML

Required Reading:
 
8:30 am-
12:20 pm
Raslich
I.2
Introduction 2
Introduction: Appreciating EBM
PPT | HTML

Required Reading:
Onady G, Raslich MA. Evidence-Based Medicine for the Pediatrician. Pediatrics in Review. 2002; 23: 318-322.
Chapter 1. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008. Pages 1-4.
Chapter 2.  Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008.  Pages 5-15.
Supplemental Reading (optional – test items will not be taken from this reading) Montori VM, Guyatt GH. Progress in Evidence-Based Medicine. JAMA. 2008; 300(15): 1814-1816.
           

Wednesday, August 5 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
 
8:00 am-
8:20 am
Raslich
I.2
Reflecting on Reflections
Introduction 2
Appreciating EBM
-
 
8:30 am-
11:20 pm
Little
0.
EBM Step 0
Identifying Information Needs
PPT | HTML

Required Reading:
Ebell, Mark. Information at the Point of Care: Answering Clinical Questions. JABFP. 1991;12:13.

Thursday, August 6 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
 
8:00 am–
8:20 am
Little 0.
Reflecting on Reflections
EBM Step 0
Identifying Information Needs		 -
 
8:30 am-
10:20 am
Sydelko
1.
EBM Step 1
Asking Answerable Clinical Questions
PPT | HTML

Required Reading:
Chapter 3. Users’ Guides to the Medical Literature. Ed. Guyatt 17-31.
 
10:30 am-
12:20 pm
Sydelko 2.
EBM Step 2
Searching for Evidence		 PPT | HTML

Required Reading:
Chapter 4. Users’ Guides to the Medical Literature. Ed. Guyatt 33-75.
PubMed BASICS
PubMed MeSH (MEdical Subject Headings)
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Week 2

Monday, August 10 - Location: 101 WH and 281 WH Computer Lab
 
Time
Lecturer
Lecture Title
Files
Media
 
8:00 am-
9:50 am
Raslich
3.
EBM Step 3
Appraising Evidence
Study Design
PPT | HTML

Required Reading:
Effective Clinical Practice. Compendium of Primers. ACP-ASIM. 32 pages
a) Type 1 and Type 2 Errors: Nov/Dec 2001 4(6).
b) Absolute vs. Relative Differences: Nov/Dec 1999 2(6).
c) Statistical Significance and P Values: Jul/Aug 2001 4(4).
d) 95% Confidence Intervals: Sept/Oct 2001 4(5).
Textbook Readings:
Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008. Optional reading on study design, p143-157.
Suggested Additional Reading:
Carney S, Doll H. Introduction to Biostatistics: Part 1. Measurement scales and their summary statistics. ACP Journal Club. July/August 2005; 143(1): A8-9.
Richardson WS, Wilson MC, Keitz SA, and Wyer PC. Tips for Teachers of Evidence-based Medicine: Making Sense of Diagnostic Test Results Using Likelihood Ratios. J Gen Intern Med. 23(1): 87–92.
 
10:00 am-
11:00 am
Sydelko
2.A
EBM Step 2
Searching for Evidence
Group A
-
 
11:05 am-
12:05 pm
Sydelko
2.B
EBM Step 2
Searching for Evidence
Group B
-
  12:10 pm -
1:10 pm
Sydelko
2.C
EBM Step 2
Searching for Evidence
Group C
-

Tuesday, August 11 - Location: 101 WH
  Time Lecturer Lecture Title Files Media
  8:00 am -
8:20 am		 Sydelko/
Raslich		 1. and 2.
Reflecting on Reflections
EBM Step 1 (Asking)
EBM Step 2 (Searching)		 -
-
  8:30 am-
10:30 am		 Onady/
Raslich		 1.
TBL
EBM Step 1
Asking Answerable Clinical Questions		 Objectives:
TBL1 Objectives
Case
Required Reading:
Onady, G., Raslich, MA. Evidence-based Medicine for the Pediatrician. Pediatr Rev. 2002;23:318-322.

Onady GM, Raslich MA. Evidence-based Medicine: Asking The Answerable Question (Question Templates as Tools) Pediatr Rev. 2003;24:265-268.


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Wednesday, August 12 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
 
8:30 am-
10:00 am
Raslich
3a.
EBM Step 3a
Appraising Evidence
Diagnosis
PPT | HTML

Required Reading:
Chapter 12. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008. 195-222.Guyatt GH, Oxman AD, Ali M, et al. Laboratory Diagnosis of Iron-Deficiency Anemia: An Overview. JGIM. 1992; 7(2):145-153.Florkowski CM. Sensitivity, Specificity, Receiver-Operating Characteristic (ROC) Curves and Likelihood Ratios: Communicating the Performance of Diagnostic Tests. Clin Biochem Rev. 2008; 29(Supp 1): S83-S87.


 
10:20 am-
12:20 pm
Raslich/
Onady		 3a.
TBL
EM Step 3a
Appraising Evidence
Diagnosis

Objectives:
TBL3a Objectives
Case

Required Reading:
Raslich MA, Onady G. Evidence-based Medicine: Critical Appraisal of the Literature (Critical Appraisal Tools). Pediatr Rev. 2007;28:132-138.

Chapter 12. Users’ Guides to the Medical Literature. Ed. Guyatt., 195-222.

Gehlbach, SH. Interpreting the Medical Literature A Clinician’s Guide. 22-37.

Gross R. Applying Evidence-based Medicine to Clinical Decision Making. 49-53.

OPTIONAL
McMurray, JJV, Pfeffer, MA. Heart Failure. Lancet. 2005;365:1877-1889. (Background reading only for students interested in reading up on current theory for heart failure.)

Using Articles
about Diagnostic Testing

 -

Thursday, August 13 - Location: 101 WH
  Time Lecturer Lecture Title Files Media
  8:00 am-
8:20 am		 Raslich 3a.
Reflecting on Reflections
EBM Step 3a
Appraising Evidence
Diagnosis		 - MP3 | Video
  8:30 am-
10:00 am		 Raslich 3b.
EBM Step 3b
Appraising Evidence
Therapy		 PPT | HTML

Required Reading:
Chapters 6 and 7. Users’ Guides to the Medical Literature. Ed. Guyatt. 85-126.
Becket NS, Peters R, Fletcher AE, et al. Treatment of Hypertension in Patients 80 Years of Age or Older. NEJM. 2008; 358(18):1887-98.Doll HA. Making Sense of the Numbers: CER, EER, ARR, RR, RRR, NNT, CI’s. The Foundation Years. 2009; 5S: 1-7.

 

 MP3 | Video
MP3 | Video
  10:20 am_
12:20 pm		 Raslich/
Onady		 3b.
TBL
EM Step 3b
Appraising Evidence
Therapy

Objectives:
TBL3b Objectives
Case
Required Reading:
Raslich MA, Onady G. Evidence-based Medicine: Critical Appraisal of the Literature (Critical Appraisal Tools). Pediatr Rev. 2007;28:132-138.

Chapter 6. Users’ Guides to the Medical Literature. Ed. Guyatt. 85-126.

Gehlbach, SH. Interpreting the Medical Literature A Clinician’s Guide. 22-37.

Gross R. Applying Evidence-Based Medicine to Clinical Decision Making. 49-53.

Using Articles
about Therapy or Prevention

Week 3

Monday, August 17 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
 
8:00 am-
8:20 am
Raslich
 3b.
Reflecting on Reflections
EBM Step 3b
Appraising Evidence
Therapy		 -
 
8:30 am-
10:00 am
 Raslich 3c.
EBM Step 3c
Appraising Evidence
Prognosis		 PPT | HTML

Required Reading:
Chapter 13. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice.
McGraw Medical. 2nd Edition;
2008, p. 223-238.
 
Goldberg RJ, Ciampa J, Lessard D, et al.Long-term Survival After Heart Failure: A Contemporary Population-Based Perspective. Archives of Internal Medicine. 2007; 167: 490-496.
 
10:20 am-
12:20 pm
Raslich/
Onady
3c.
TBL
EBM Step 3c
Appraising Evidence
Prognosis

Objectives:
TBL3c Objectives
Case

Required Reading:
Raslich MA, Onady G. Evidence-Based Medicine: Critical Appraisal of the Literature (Critical Appraisal Tools). Pediatr Rev. 2007;28:132-138.

Chapter 13. Users’ Guides to the Medical Literature. Ed. Guyatt. 223-238.

Gehlbach SH. Interpreting the Medical Literature A Clinician’s Guide. 22-37.

Gross R. Applying Evidence-Based Medicine to Clinical Decision Making. 49-53.

Using Articles
About Prognosis

 -

Tuesday, August 18 - Location: 101 WH
  Time Lecturer Lecture Title Files Media
  8:00 am-
8:20 am		 Raslich 3c.
Reflecting on Reflections
EBM Step 3c
Appraising Evidence
Prognosis		 - MP3 | Video
  8:30 am-
9:00 am		 Little 4.
EBM Step 4
Applying Evidence		 PPT | HTML
 
Required Reading:
Optional Reading: Kerkhoffs GMMJ, Rowe BH, Assendelft WJJ, Kelly KD, Struijs PAA, van Dijk CN. Immobilization and functional treatment for acute lateral ankle ligament injuries in adults. Cochrane Database of Systematic Reviews, 2002, Issue 3. Art. No.: CD003762. DOI: 10.1002/14651858.CD003762.
  9:10 am-
10:00 am		 Little 4a.
EBM Step 4a
Applying Evidence
Diagnosis		 PPT | HTML

  Required Reading:
Chapter 12. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition;
2008. Pages 214-221.
 
Laupacis A, Sekar N, Stiell IG. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA. 1997 Feb 12; 277(6): 488-94.
 
Stiell IG, Greenberg GH, McKnight RD, et al. Decision Rules for the Use of Radiography in Acute Ankle Injuries: Refinement and Prospective Validation. JAMA. 1993; 269: 1127- 1132.
 
Optional Readings
Stiell IG, Greenberg GH, McKnight RD, et al. A study to develop clinical decision rules for the use of radiography in acute ankle injuries. Annals of Emergency Medicine 1992;21:384-390. Auleley GR, Ravaud P, Giraudeau B, et al. Implementation of the Ottawa ankle rules in France: A multicenter randomized controlled trial. JAMA. 1997;277:1935-1939. Wang L, Prentiss KA, Simon JZ, et al. The use of the white blood cell count and left shift in the diagnosis of appendicitis in children. Pediatric Emergency Care. 2007;23(2):69-76. Getchell WS, Larsen GC, Morris CD, et al. Epidemiology of syncope in hospitalized patients. J Gen Intern Med 1999 Nov; 14(11): 677-87.
 
 MP3 | Video
  10:10 am-
11:00 am		 Little 4b.
EBM Step 4b
Applying Evidence
Therapy		 PPT | HTML
 
Required Reading:
Chapter 6. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008. Pages 103-108.
 
Yusuf S, Wittes J, Probstfield J, et al. Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA 1991;266:93-98.
 
Stiell IG, Greenberg GH, McKnight RD, et al. A study to develop clinical decision rules for the use of radiography in acute ankle injuries. Annals of Emergency Medicine 1992;21:384-390.
 
Optional Readings:
Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for Asymptomatic Carotid Artery Stenosis. JAMA. 1995;273:1421-1428.
 
Assmann SF, Pocock SJ, Enos LE, et al. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 2000; 355: 1064–69.

ISIS-2 (Second international study of infarct survival) collaborative group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction. Lancet 1988;8607:349- 360.		 MP3 | Video
  11:10 am-
12:00 pm		 Little 4c.
EBM Step 4c
Applying Evidence
Prognosis		 PPT | HTML 
 
Required Reading:
Chapter 13. Users’ Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. McGraw Medical. 2nd Edition; 2008. Pages 234-237. Kerr CR, Humphries KH, Talajic M, et al. Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: Results from the Canadian Registry of Atrial Fibrillation. American Heart Journal 2005;149:489-96.
 
Optional Readings:
Braun BL. Effects of ankle sprain in a general clinic population 6 to 18 months after medical evaluation. Archives of Family Medicine 1999;8:143-148. 		MP3 | Video
  - Little Applying -- Worksheets Worksheets:
Diagnosis
Therapy
Prognosis		 -
  2:00 pm-
4:00pm		 Raslich Study Design OR Review PPT | HTML MP3 | Video

Wednesday, August 19 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
 
8:00 am–
8:20 am
 Little
4.
Reflecting on Reflections
EBM Step 4
Applying Evidence		 -
  8:30 am–
10:30 am		 Onady/
Little		 4.
TBL
EBM Step 4 --
Applying Evidence		 Objectives:
TBL4 Objectives
Case

Required Reading:
Onady G. Evidence-based Medicine: Applying Valid Evidence. Pediatr Rev. 2009;30:132-138.

Raslich MA, Onady G. Evidence-based Medicine: Critical Appraisal of the Literature (Critical Appraisal Tools). Pediatr Rev. 2007;28:132-138. (Reference Use for Application Only)

Chapter 11. Users’ Guides to the Medical Literature. Ed. Guyatt. 179-193.
-
 
10:45 am-11:45 am
Raslich Reviewing STATS  

Thursday, August 20 - Location: 101 WH
  Time Lecturer Lecture Title Files Media
  8:00 am–
8:20 am		 Onady 5.
EBM Step 5
Integrating Evidence 		Required Reading:
Case
 MP3 | Video
  8:45 am-
11:00 am		 Onady/
Little/
Raslich		 5.
TBL
EBM Step 5
Integrating Evidence		 Objectives:
TBL5 Objectives

Required Reading:
Gross R. Applying Evidence-based Medicine to Clinical Decision Making. Mosby. Philadelphia, PA. 2001. Read pages: 74-95,118-129, 160-161,174-177. Gross R. Making Medical Decisions. ACP-ASIM. Philadelphia PA.1999. pp. 21-33. Goodlin SJ, Quill TE, Arnold RM. Communication and Decisionmaking About Prognosis in Heart Failure Care. J Card Failure. 2008;14:106-113.
 -
  11:00 am-
12:00 pm		 Raslich Reviewing STATS   MP3 | Video

Friday, August 21 - Location: 101 WH
 
Time
Lecturer
Lecture Title
Files
Media
  8:00 am-
8:20 am		 Onady/
Little/
Raslich
5.
Reflecting on Reflections
EBM Step 5
Integrating Evidence		 -
MP3 | Video
  8:30 am-11:30 am Little/
Onady/
Parmelee/
Raslich/
Sydelko 		6.Project
EBM CATstone
Writing a Critically Appraised Topic (CAT)
Reading for ALL Teams:
CATstone Exercise Process
 
CATstone Description
 
CATstone Example
 
CATstone Scoring Sheet

Reading for Teams D 1-6:
Article Diagnosis - to create CAT
 
Template Diagnosis - to create CAT
 
Abstract Therapy - to review CAT
 
Reading for Teams T 7-12:
Article Therapy - to create CAT
 
Template Therapy - to create CAT
 
Abstract Prognosis - to review CAT
 
Reading for Teams P 13-17:
Article Prognosis - to create CAT
 
Template Prognosis - to create CAT
 
Abstract Diagnosis - to review CAT
 
MP3 | Video


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Week 4

Monday, August 24 - Location: 261, 271, 281 Computer Labs WH
  9:00 am    CDM Final Exam
         

 
Last updated 11/20/09 . (dsh). For more information, contact the Boonshoft School of Medicine Academic Affairs.